Using guitar chords (not shapes)

Dumb question from a mere strummer (not fingerpicker, etc). If I can’t find uke strum chords for a song, I can try its guitar chords, right? Not the shapes, but the named chords (C-F-G, etc)? Might not fit every song (low G difference, etc.), but shouldn’t it work generally? Or am I missing something? Thanks for any insights!